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2024 Feb;46(2):e64-e72

Study Design: Participants included overweight and obese patients, some with concomitant conditions such as type 2 diabetes

Trigonelline, an alkaloid extracted from fenugreek seeds, can reduce hepatic FMO3 activity, inhibit TMA oxidation, and decrease TMAO production, thereby slowing the progression of CKD (Yong et al., 2023) (Figure 9B)